منابع مشابه
Epigenetic asymmetry in the zygote and mammalian development.
In mammals, the maternal and the paternal genome are not functionally equivalent and are both required for embryonic and postnatal development. The genome is organised differently in the oocyte as compared to sperm, in which the DNA is tightly packaged with protamines rather than with histones. The requirement of both the parental genomes for normal development is a consequence of differential ...
متن کاملOverexpression of ORC subunits and increased ORC-chromatin association in transformed mammalian cells.
The origin recognition complex (ORC) is a conserved heterohexamer required for the formation of pre-replication (pre-RC) complexes at origins of DNA replication. Many studies of ORC subunits have been carried out in transformed human cell lines but the properties of ORC in primary cells have not been addressed. Here, we compare the expression levels and chromatin-association of ORC subunits in ...
متن کاملSubsets of human origin recognition complex (ORC) subunits are expressed in non-proliferating cells and associate with non-ORC proteins.
The origin recognition complex (ORC) in yeast is a complex of six tightly associated subunits essential for the initiation of DNA replication. Human ORC subunits are nuclear in proliferating cells and in proliferative tissues like the testis, consistent with a role of human ORC in DNA replication. Orc2, Orc3, and Orc5 also are detected in non-proliferating cells like cardiac myocytes, adrenal c...
متن کاملThe Orc Quest Example
Resource-based planning systems have recently begun to mushroom | an indication that AI planning systems have nally started to tackle real-world problems. However, resources tend to be neglected. Conventional plan length is still the primary optimization goal, resources being of only secondary importance. This paper illustrates the problem and gives an overview of the Excalibur agent's planning...
متن کاملThe Orc Programming Language
Orc was originally presented as a process calculus. It has now evolved into a full programming language, which we describe in this paper. The language has the structure and feel of a functional programming language, yet it handles many non-functional aspects effectively, including spawning of concurrent threads, time-outs and mutable state. We first describe the original concurrency combinators...
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ژورنال
عنوان ژورنال: Cell and Tissue Research
سال: 2015
ISSN: 0302-766X,1432-0878
DOI: 10.1007/s00441-015-2296-3